Teaching code

4S01610

Credits

8

Coordinatore

Patrizia Scapini

Language

Italian

Also offered in courses:

• Technical and medical sciences - PATOLOGIA GENERALE of the course Bachelor's degree in Orthopaedics Techniques

Moodle Seminars

The teaching is organized as follows:

Learning outcomes

The course integrates areas of biomedical knowledge dedicated to the pathogenesis and drug therapy of the most frequent pathologies in the professional field of interest. The objectives of the course are: 1- To know and to analyze the main mechanisms of cellular and molecular damage and repairing reactions by acquiring the ability to evaluate the most relevant macroscopic lesions 2- Acquire the basis for a rational understanding of the major pathologies relevant to the perfusionist medical practice; in particular, due to the specificity of the professional practice, particular attention will be given to the general and specific aspects of prokaryotic systems. 3- Integrate the knowledge acquired in points 1 and 2 with the main guidelines of pharmacodynamics and kinetics in order to be able to define and understand the rational basis of drug therapy of the pathological conditions of greatest interest for the professional field. PATHOLOGICAL ANATOMY MODULE Educational objectives: To recognize the main macroscopic and microscopic lesions in the gross room and histopathology. To perform macroscopic evaluation of the main organs: heart, lungs, kidney, brain and liver. To perform histopathological evaluation of inflammatory, neoplastic and malformative lesions on common H&E tissue slides. To recognize the add-value of the main laboratory techniques in Pathology Lab and useful for diagnostics such as immunohistochemistry, FISH (fluorescence in situ hybridization) and mutational analysis. GENERAL PHARMACOLOGY MODULE. Educational objectives: General objectives: The student understands the meaning of drug interaction, the basics of the generation of therapeutic and undesirable effects; knows the functional differences of the different preparations of a drug, the main pharmacokinetic concepts and the implications for the therapeutic plan. The student knows the mechanisms of action, the effects, the indications for use and the main side effects of the most important classes of drugs for the treatment of the cardiovascular disease. Specific objectives: at the end of the Pharmacology module, the student will be in possession of the scientific and operational knowledge useful to: • understand the mechanisms of action of drugs that underlie their main, side and toxic effects; • know and understand the methods of clinical evaluation of drugs and their post-marketing monitoring; • understand the bases of the rational approach of the drug administration; • understand the use, and know the associated risks, of the most important classes of drugs for the treatment of the cardiovascular diseases. CLINICAL MICROBIOLOGY MODULE The student should know the structural and biological properties of pathological microorganisms and the related mechanism of pathogenesis. Moreover, the student should know the microorganisms involved in cardiopulmonary diseases and the methods of infection diagnosis. GENERAL PATHOLOGY MODULE Educational objectives: The course aims to illustrate the main mechanisms of cellular and molecular damage and reactions to biological damage, with particular focus to the description of the inflammatory processes resulting in healing or chronicization and of the hemostatic mechanisms occurring in response to vascular damage.

Program

The course is divided in 4 modules: General and Anatomic Pathology, Clinical Microbiology and Pharmacology
The programme of General Pathology concern the concept of disease with special reference to the inflammation process, its molecular and cellular components, the signaling involved and its development and evolution as defensive event.
The programme of Anatomic Pathology will cover the gross sampling of heart, CNS, lung and kidney and the histopathology of major neoplastic, preneoplastic and inflammatory diseases.
The programme of the module of clinical microbiology focus on the structural and biochemical organization of micro-organisms (bacteria, virus, yeast, protozoa). Special emphasis will be given to knowledge required for elaborating accurate diagnosis in clinical microbiology, with focus on infections affecting cardio-vascular system and/or generating sepsis and nosocomial problems.
The programme of General Pharmacology will provide the knowledge on drug/receptor interaction, generation of effects (therapeutic and adverse reactions) and pharmacokinetics/metabolism. The module will focus on classes of drugs used for the control of cardio-vascular disorders.

Bibliography

Examination Methods

Oral/written (multiple choice/free) depending on individual module; final score is computed opn the basis of results of individual module (weighted based on % CFU)