Teaching code

4S007458

Academic staff

Stefano Augusto Maria Biressi, Giovanni Provenzano

Coordinator

Stefano Augusto Maria Biressi

Credits

6

Language

Italian

Scientific Disciplinary Sector (SSD)

BIO/11 - MOLECULAR BIOLOGY

Period

2° semestre SM dal Feb 26, 2024 al May 30, 2024.

Location

ROVERETO

Courses Single

Authorized with reserve

Lessons timetable Moodle Seminars 0

Learning objectives

The course provides students with the fundamental concepts for the comprehension of molecular mechanisms operating at the cellular and tissue level in response to physical exercise and hypoxia. At the end of this course the students will be able to: 1. comprehensively describe the adaptive responses to exercise and hypoxia; 2. fully understand the main cellular responses operating in the context of adaptation; 3. explain in depth the molecular mechanisms underlying paradigmatic adaptive responses; 4. integrate molecular, cellular and systemic mechanisms of adaptation; 5. critically analyze the acquired knowledge in the physiopathological and sports context The course provides students with the fundamental concepts for the comprehension of molecular mechanisms operating at the cellular and tissue level in response to physical exercise and hypoxia. At the end of this course the students will be able to: 1. comprehensively describe the adaptive responses to exercise and hypoxia; 2. fully understand the main cellular responses operating in the context of adaptation; 3. explain in depth the molecular mechanisms underlying paradigmatic adaptive responses; 4. integrate molecular, cellular and systemic mechanisms of adaptation; 5. critically analyze the acquired knowledge in the physiopathological and sports context The course provides students with the fundamental concepts for the comprehension of molecular mechanisms operating at the cellular and tissue level in response to physical exercise and hypoxia. At the end of this course the students will be able to: 1. comprehensively describe the adaptive responses to exercise and hypoxia; 2. fully understand the main cellular responses operating in the context of adaptation; 3. explain in depth the molecular mechanisms underlying paradigmatic adaptive responses; 4. integrate molecular, cellular and systemic mechanisms of adaptation; 5. critically analyze the acquired knowledge in the physiopathological and sports context

Prerequisites and basic notions

Basic knowledge of biochemistry and biology.

Program

The course will be divided into two modules in which the following topics will be discussed:
1. Adaptative responses to the exercise:
- The integrated response to the exercise;
- Exercise and energy metabolism;
- Exercise-induced muscular hypertrophy: molecular signaling pathways involved, transcriptional mechanisms and control of protein synthesis;
- Stem cells and adaptive muscle response;
- Myokines and exercise;
- Exercise and brain.
2. Adaptive responses to hypoxia:
- Cellular and molecular mechanisms of oxygen sensing;
- Cellular and molecular responses to hypoxia: transcriptional mechanisms and control of protein synthesis;
- Epigenetic response to hypoxia;
- Muscle response to hypoxia: implications of physical exercise;
- Chronic and acute Hypoxia;
- Human evolution in altitude;
- Hints to molecular mechanisms of doping
-Hypoxia and apnea.

Bibliography

Didactic methods

Lessons consist of frontal lectures (with slides), including group discussions of experimental evidence to support the illustrated concepts. The classes will be held in Italian. The reference material will be mainly in English. In addition to slides, the student may make use of scientific articles that will be indicated and the following texts:
1. Zierath J.R., Joyner M.J., Hawley J.A. (2017). The Biology of Exercise COLD SPRING HARBOR LABORATORY PRESS
2. Swenson E.R., Bartsch P. (2014). High Altitude: Human Adaptation to Hypoxia. Springer.
3. Speigelman B. (2017). Hormones, Metabolism asnd the Benefits of Exercise. Springer.
4. Roach R.C., Wagner P.D., Hackett P.H. (2016). Hypoxia: Translation in Progress. Springer.

Learning assessment procedures

The exam's objective consists of verifying the level of achievement of the previously indicated training objectives.
The exam consists of an oral interview with the teachers in which questions addressed in the course will be discussed.

Evaluation criteria

The accuracy and completeness of knowledge, the precision of expression and the ability to make connections and critical re-elaboration will be evaluated.

Criteria for the composition of the final grade

The final grade results from the synthesis of the opinions of both teachers.

Exam language

Italiano (Inglese solo se specificamente richiesto dagli studenti)