Training and Research
PhD Programme Courses/classes - 2024/2025
This page shows the PhD course's training activities for the academic year 2024/2025. Further activities will be added during the year. Please check regularly for updates!
Coagulation and Asthma
Credits: 0,5
Language: Italiano
Teacher: Nicola Martinelli
Enzymes involved in rare neurotransmitter diseases: approaches to genotype-phenotype correlation
Credits: 0,5
Language: Italian
Teacher: Mariarita Bertoldi
Epigenomica della bilancia emostatica
Credits: 0,5
Language: English
Teacher: Simonetta Friso
Heme and Iron toxicity in hemoglobinopathies
Credits: 0,5
Language: Italian
Teacher: Lucia De Franceschi
Hypereosinophilic Syndromes
Credits: 0,5
Language: Italiano, inglese su richiesta per gli studenti Erasmus
Teacher: Marco Caminati
Improvement of Plasmodium Falciparum clearance in phase 2 study with triple anti-malarial therapy
Credits: 0,5
Language: Italian
Teacher: Lucia De Franceschi
Investigating hematopoiesis with novel 3D bone marrow models
Credits: 0,5
Language: Italian
Teacher: Lucia De Franceschi
In Vps13a-/- Mice, the Impairment of Autophagy Exacerbates Skeletal Muscle Aging Phenotype
Credits: 0,5
Language: Italian
Teacher: Lucia De Franceschi
Iron in health and diseases
Credits: 0,5
Language: Italian
Teacher: Domenico Girelli
MicroRNAs drive ibrutinib resistance in mantle cell lymphoma via the AKT/PIK3 and MAPK pathways
Credits: 0,5
Language: English
Teacher: Carlo Visco
Mutant-p53 induces ferroptosis resistance in pancreatic cancer
Credits: 0,5
Language: Italian
Teacher: Alessandra Fiore
Phenotyping pain in arthritis: dissecting inflammatory and non-inflammatory mechanisms
Credits: 0,5
Language: Italian
Teacher: Lucia De Franceschi
Plasma fatty acid analysis in hypertensive patients affected by Primary Aldosteronism highlights specific lipidic profile differences with Essential Hypertension
Credits: 0,5
Language: Italian
Teacher: Francesca Pizzolo
Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina
Credits: 0,5
Language: Italian
Teacher: Valerio Marino
Translational medicine: trilayer scaffolds for the repair of osteochondral defects
Credits: 1
Language: english
Teacher: Luca Giuseppe Dalle Carbonare, Elena Manuela Samaila
γ-aminobutyrate(GABA)-transaminase: molecular and cellular approaches to the study of the structure-function relationships of the enzyme
Credits: 0,5
Language: English
Teacher: Riccardo Montioli
MicroRNAs drive ibrutinib resistance in mantle cell lymphoma via the AKT/PIK3 and MAPK pathways (2024/2025)
Teacher
Referent
Credits
0.5
Language
English
Class attendance
Free Choice
Location
VERONA
Learning objectives
Chronic activation of the Bruton’s tyrosine kinase (BTK)-mediated B-cell receptor (BCR) signaling characterizes various B-cell lymphoid malignancies, including mantle cell lymphoma (MCL). While BTK inhibitors effectively target this pathway in relapsed or refractory MCL, resistance to single-agent ibrutinib is common. Studies elucidating the intricate networks responsible for therapeutic resistance are ongoing.
MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have a crucial role in cancer development and drug response. However, their role in ibrutinib resistance in MCL is yet to be elucidated.
To this end, we generated three ibrutinib-resistant (IR) clones (Jeko_R, Mino_R and Rec_R) by chronic exposure to ibrutinib. IR clones exhibited unique miRNAome and transcriptome signatures. Downregulation of miRNAs regulating survival pathways like MAPK-ERK and PI3K cascade was observed in IR cells, patient-derived xenografts (PDX), and IR MCL biopsies. Consequently, these pathways were highly expressed in IR MCL.
Treatment with cobimetinib (MEKi), idelalisib (PI3Ki), capivasertib (AKTi), and their combination, significantly inhibited these pathways, reducing cell proliferation. Moreover, restoring miRNA expression abrogated the resistance and sensitized the cells to ibrutinib treatment.
These findings reveal that miRNAs upregulate prosurvival pathways in IR MCL, contributing to drug resistance. Targeting these pathways with existing inhibitors presents novel strategies for overcoming resistance.
Prerequisites and basic notions
Degree
Program
Chronic activation of the Bruton’s tyrosine kinase (BTK)-mediated B-cell receptor (BCR) signaling characterizes various B-cell lymphoid malignancies, including mantle cell lymphoma (MCL). While BTK inhibitors effectively target this pathway in relapsed or refractory MCL, resistance to single-agent ibrutinib is common. Studies elucidating the intricate networks responsible for therapeutic resistance are ongoing.
MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have a crucial role in cancer development and drug response. However, their role in ibrutinib resistance in MCL is yet to be elucidated.
To this end, we generated three ibrutinib-resistant (IR) clones (Jeko_R, Mino_R and Rec_R) by chronic exposure to ibrutinib. IR clones exhibited unique miRNAome and transcriptome signatures. Downregulation of miRNAs regulating survival pathways like MAPK-ERK and PI3K cascade was observed in IR cells, patient-derived xenografts (PDX), and IR MCL biopsies. Consequently, these pathways were highly expressed in IR MCL.
Treatment with cobimetinib (MEKi), idelalisib (PI3Ki), capivasertib (AKTi), and their combination, significantly inhibited these pathways, reducing cell proliferation. Moreover, restoring miRNA expression abrogated the resistance and sensitized the cells to ibrutinib treatment.
These findings reveal that miRNAs upregulate prosurvival pathways in IR MCL, contributing to drug resistance. Targeting these pathways with existing inhibitors presents novel strategies for overcoming resistance.
Didactic methods
Oral lesson
Learning assessment procedures
Oral
Assessment
Topic learning and translational reasoning skills
Criteria for the composition of the final grade
30/30
PhD school courses/classes - 2024/2025
Please note: Additional information will be added during the year. Currently missing information is labelled as “TBD” (i.e. To Be Determined).
1. PhD students must obtain a specified number of CFUs each year by attending teaching activities offered by the PhD School.
First and second year students must obtain 8 CFUs. Teaching activities ex DM 226/2021 provide 5 CFUs; free choice activities provide 3 CFUs.
Third year students must obtain 4 CFUs. Teaching activities ex DM 226/2021 provide 2 CFUs; free choice activities provide 2 CFUs.
More information regarding CFUs is found in the Handbook for PhD Students: https://www.univr.it/phd-vademecum
2. Registering for the courses is not required unless explicitly indicated; please consult the course information to verify whether registration is required or not. When registration is actually required, instructions will be sent well in advance. No confirmation e-mail will be sent after signing up. Please do not enquiry: if you entered the requested information, then registration was silently successful.
3. When Zoom links are not explicitly indicated, courses are delivered in presence only.
4. All information we have is published here. Please do not enquiry for missing information or Zoom links: as soon as we get new information, we will promptly publish it on this page.
Ambito per Dottorati
Ambito per i Corsi di Dottorato
Teaching Activities ex DM 226/2021: Linguistic Activities
ENGLISH FOR ACADEMIC PRESENTATION SKILLS [Arts and Humanities]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC PRESENTATION SKILLS [Law and Economics]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC PRESENTATION SKILLS [Life and Health Sciences - 1 st Session]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC PRESENTATION SKILLS [Life and Health Sciences - 2 nd Session]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC WRITING SKILLS [Arts and Humanities]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC WRITING SKILLS [Law and Economics]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC WRITING SKILLS [Life and Health Sciences - 1 st Session]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC WRITING SKILLS [Life and Health Sciences - 2 nd Session]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC WRITING SKILLS [Natural Sci. and Engineering-1st Session]
Credits: 2,5
Language: English
ENGLISH FOR ACADEMIC WRITING SKILLS [Natural Sci. and Engineering-2nd Session]
Credits: 2,5
Language: English
Teaching Activities ex DM 226/2021: Other Free choice activities
DOTTORATO E MERCATO DEL LAVORO: WORKSHOP FORMATIVI PER DOTTORANDI E NEO-DOTTORI DI RICERCA
Credits: 4
Language: Italian
ARE YOU SURE YOU CAN DEFEAT A CHATBOT?
Credits: 1
Language: Italian
MEETING UKRAINE: THE IMPACT OF WAR AND FUTURE OPPORTUNITIES
Credits: 1
Language: Italian
EMOTIONS, BELIEFS, AND SKILLS TO FACE CLIMATE CHANGE AND EMBRACE CLIMATE ACTION
Credits: 0,5
Language: English
Teaching Activities ex DM 226/2021: Research management and Enhancement
SEMINARIO AVANZATO SULLE RISORSE BIBLIOTECARIE PER LA RICERCA [Arts and Humanities]
Credits: 2,5
Language: Italian
SEMINARIO AVANZATO SULLE RISORSE BIBLIOTECARIE PER LA RICERCA [Law and Economics]
Credits: 2,5
Language: Italian
SEMINARIO AVANZATO SULLE RISORSE BIBLIOTECARIE PER LA RICERCA [Scientific Area]
Credits: 2,5
Language: Italian
Teaching Activities ex DM 226/2021: Statistics and Computer Sciences
APPLICATION OF META-ANALYSIS TO THE EPIDEMIOLOGICAL OR MEDICAL FIELD
Credits: 1
Language: English
Teacher: Giuseppe Verlato
CORSO STATISTICA - LIVELLO INTERMEDIO
Credits: 2,5
Language: English
DETERMINATION OF SAMPLE SIZE TO ACHIEVE A PREDEFINED PRECISION OR POWER
Credits: 0,5
Language: English
Teacher: Giuseppe Verlato
Survival analysis: log-rank test, Kaplan-Meier survival curves, Cox regression model
Credits: 1,5
Language: English - Inglese
Teacher: Simone Accordini
USO DI R PER L'ANALISI STATISTICA - LIVELLO INTERMEDIO
Credits: 0,8
Language: English
Teacher: Alessandro Mantovani
Teaching Activities: Free choice
Faculty
marco.benati@univr.it
+39 045 812 4418 - 6698
PhD students
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Guidelines for PhD students
Below you will find the files that contain the Guidelines for PhD students and rules for the acquisition of ECTS credits (in Italian: "CFU") for the Academic Year 2023/2024.
