Formazione e ricerca
Attività Formative del Corso di Dottorato - 2024/2025
In questa pagina sono riportate le attività formative del corso di dottorato per l'anno accademico 2024/2025. Ulteriori attività verranno aggiunte durante l'anno. Ti invitiamo a verificare regolarmente la presenza di aggiornamenti!
Coagulation and Asthma
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Nicola Martinelli
Enzymes involved in rare neurotransmitter diseases: approaches to genotype-phenotype correlation
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Mariarita Bertoldi
Epigenomics of the hemostatic balance
Crediti: 0,5
Lingua di erogazione: English
Docente: Simonetta Friso
Heme and Iron toxicity in hemoglobinopathies
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Lucia De Franceschi
Hypereosinophilic Syndromes
Crediti: 0,5
Lingua di erogazione: Italiano, inglese su richiesta per gli studenti Erasmus
Docente: Marco Caminati
Improvement of Plasmodium Falciparum clearance in phase 2 study with triple anti-malarial therapy
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Lucia De Franceschi
Investigating hematopoiesis with novel 3D bone marrow models
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Lucia De Franceschi
In Vps13a-/- Mice, the Impairment of Autophagy Exacerbates Skeletal Muscle Aging Phenotype
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Lucia De Franceschi
Iron in health and diseases
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Domenico Girelli
MicroRNAs drive ibrutinib resistance in mantle cell lymphoma via the AKT/PIK3 and MAPK pathways
Crediti: 0,5
Lingua di erogazione: English
Docente: Carlo Visco
Mutant-p53 induces ferroptosis resistance in pancreatic cancer
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Alessandra Fiore
Phenotyping pain in arthritis: dissecting inflammatory and non-inflammatory mechanisms
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Lucia De Franceschi
Plasma fatty acid analysis in hypertensive patients affected by Primary Aldosteronism highlights specific lipidic profile differences with Essential Hypertension
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Francesca Pizzolo
Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina
Crediti: 0,5
Lingua di erogazione: Italiano
Docente: Valerio Marino
Translational medicine: trilayer scaffolds for the repair of osteochondral defects
Crediti: 1
Lingua di erogazione: english
Docente: Luca Giuseppe Dalle Carbonare, Elena Manuela Samaila
γ-aminobutyrate(GABA)-transaminase: molecular and cellular approaches to the study of the structure-function relationships of the enzyme
Crediti: 0,5
Lingua di erogazione: English
Docente: Riccardo Montioli
MicroRNAs drive ibrutinib resistance in mantle cell lymphoma via the AKT/PIK3 and MAPK pathways (2024/2025)
Docente
Referente
Crediti
0,5
Lingua di erogazione
English
Frequenza alle lezioni
Scelta Libera
Sede
VERONA
Obiettivi di apprendimento
Chronic activation of the Bruton’s tyrosine kinase (BTK)-mediated B-cell receptor (BCR) signaling characterizes various B-cell lymphoid malignancies, including mantle cell lymphoma (MCL). While BTK inhibitors effectively target this pathway in relapsed or refractory MCL, resistance to single-agent ibrutinib is common. Studies elucidating the intricate networks responsible for therapeutic resistance are ongoing.
MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have a crucial role in cancer development and drug response. However, their role in ibrutinib resistance in MCL is yet to be elucidated.
To this end, we generated three ibrutinib-resistant (IR) clones (Jeko_R, Mino_R and Rec_R) by chronic exposure to ibrutinib. IR clones exhibited unique miRNAome and transcriptome signatures. Downregulation of miRNAs regulating survival pathways like MAPK-ERK and PI3K cascade was observed in IR cells, patient-derived xenografts (PDX), and IR MCL biopsies. Consequently, these pathways were highly expressed in IR MCL.
Treatment with cobimetinib (MEKi), idelalisib (PI3Ki), capivasertib (AKTi), and their combination, significantly inhibited these pathways, reducing cell proliferation. Moreover, restoring miRNA expression abrogated the resistance and sensitized the cells to ibrutinib treatment.
These findings reveal that miRNAs upregulate prosurvival pathways in IR MCL, contributing to drug resistance. Targeting these pathways with existing inhibitors presents novel strategies for overcoming resistance.
Prerequisiti e nozioni di base
Degree
Programma
Chronic activation of the Bruton’s tyrosine kinase (BTK)-mediated B-cell receptor (BCR) signaling characterizes various B-cell lymphoid malignancies, including mantle cell lymphoma (MCL). While BTK inhibitors effectively target this pathway in relapsed or refractory MCL, resistance to single-agent ibrutinib is common. Studies elucidating the intricate networks responsible for therapeutic resistance are ongoing.
MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have a crucial role in cancer development and drug response. However, their role in ibrutinib resistance in MCL is yet to be elucidated.
To this end, we generated three ibrutinib-resistant (IR) clones (Jeko_R, Mino_R and Rec_R) by chronic exposure to ibrutinib. IR clones exhibited unique miRNAome and transcriptome signatures. Downregulation of miRNAs regulating survival pathways like MAPK-ERK and PI3K cascade was observed in IR cells, patient-derived xenografts (PDX), and IR MCL biopsies. Consequently, these pathways were highly expressed in IR MCL.
Treatment with cobimetinib (MEKi), idelalisib (PI3Ki), capivasertib (AKTi), and their combination, significantly inhibited these pathways, reducing cell proliferation. Moreover, restoring miRNA expression abrogated the resistance and sensitized the cells to ibrutinib treatment.
These findings reveal that miRNAs upregulate prosurvival pathways in IR MCL, contributing to drug resistance. Targeting these pathways with existing inhibitors presents novel strategies for overcoming resistance.
Modalità didattiche
Oral lesson
Modalità di verifica dell'apprendimento
Orale
Valutazione
Apprendimento dell'argomento e capacità di ragionamento traslazionale
Criteri di composizione del voto finale
30/30
Attività Formative della Scuola di Dottorato - 2024/2025
Please note: Additional information will be added during the year. Currently missing information is labelled as “TBD” (i.e. To Be Determined).
1. PhD students must obtain a specified number of CFUs each year by attending teaching activities offered by the PhD School.
First and second year students must obtain 8 CFUs. Teaching activities ex DM 226/2021 provide 5 CFUs; free choice activities provide 3 CFUs.
Third year students must obtain 4 CFUs. Teaching activities ex DM 226/2021 provide 2 CFUs; free choice activities provide 2 CFUs.
More information regarding CFUs is found in the Handbook for PhD Students: https://www.univr.it/phd-vademecum
2. Registering for the courses is not required unless explicitly indicated; please consult the course information to verify whether registration is required or not. When registration is actually required, instructions will be sent well in advance. No confirmation e-mail will be sent after signing up. Please do not enquiry: if you entered the requested information, then registration was silently successful.
3. When Zoom links are not explicitly indicated, courses are delivered in presence only.
4. All information we have is published here. Please do not enquiry for missing information or Zoom links: as soon as we get new information, we will promptly publish it on this page.
Ambito per Dottorati
Ambito per i Corsi di Dottorato
Teaching Activities ex DM 226/2021: Linguistic Activities
ENGLISH FOR ACADEMIC PRESENTATION SKILLS [Arts and Humanities]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC PRESENTATION SKILLS [Law and Economics]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC PRESENTATION SKILLS [Life and Health Sciences - 1 st Session]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC PRESENTATION SKILLS [Life and Health Sciences - 2 nd Session]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC WRITING SKILLS [Arts and Humanities]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC WRITING SKILLS [Law and Economics]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC WRITING SKILLS [Life and Health Sciences - 1 st Session]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC WRITING SKILLS [Life and Health Sciences - 2 nd Session]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC WRITING SKILLS [Natural Sci. and Engineering-1st Session]
Crediti: 2,5
Lingua di erogazione: Inglese
ENGLISH FOR ACADEMIC WRITING SKILLS [Natural Sci. and Engineering-2nd Session]
Crediti: 2,5
Lingua di erogazione: Inglese
Teaching Activities ex DM 226/2021: Other Free choice activities
Teaching Activities ex DM 226/2021: Research management and Enhancement
SEMINARIO AVANZATO SULLE RISORSE BIBLIOTECARIE PER LA RICERCA [Arts and Humanities]
Crediti: 2,5
Lingua di erogazione: Italiano
SEMINARIO AVANZATO SULLE RISORSE BIBLIOTECARIE PER LA RICERCA [Law and Economics]
Crediti: 2,5
Lingua di erogazione: Italiano
SEMINARIO AVANZATO SULLE RISORSE BIBLIOTECARIE PER LA RICERCA [Scientific Area]
Crediti: 2,5
Lingua di erogazione: Italiano
Teaching Activities ex DM 226/2021: Statistics and Computer Sciences
APPLICATION OF META-ANALYSIS TO THE EPIDEMIOLOGICAL OR MEDICAL FIELD
Crediti: 1
Lingua di erogazione: Inglese
Docente: Giuseppe Verlato
CORSO STATISTICA - LIVELLO INTERMEDIO
Crediti: 2,5
Lingua di erogazione: Inglese
DETERMINATION OF SAMPLE SIZE TO ACHIEVE A PREDEFINED PRECISION OR POWER
Crediti: 0,5
Lingua di erogazione: Inglese
Docente: Giuseppe Verlato
SURVIVAL ANALYSIS: LOG-RANK TEST, KAPLAN-MEIER SURVIVAL CURVES, COX REGRESSION MODEL
Crediti: 1,5
Lingua di erogazione: English - Inglese
Docente: Simone Accordini
USO DI R PER L'ANALISI STATISTICA - LIVELLO INTERMEDIO
Crediti: 0,8
Lingua di erogazione: Inglese
Docente: Alessandro Mantovani
Teaching Activities: Free choice
Docenti
marco.benati@univr.it
+39 045 812 4418 - 6698
Dottorandi
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Linee guida percorso formativo
Di seguito i file che contengono le Linee guida per il percorso formativo e il regolamento per l'acquisizione dei crediti formativi (CFU) per l'Anno Accademico 2023/2024.
