The teaching is organized as follows:

Learning objectives

The educational objectives of the course are the learning of knowledge in the field of Clinical Pharmacology as it is implemented in the complexity and variability of the different clinical conditions, chronicity and personalization in the field of pharmacotherapy and chemotherapy. The student will learn:
• factors and clinical conditions influencing biotransformation: age; pregnancy; race (polymorphism); diet; pathologies; sex; route of drug administration; drug induction and inhibition of metabolism.
• factors and clinical conditions influencing renal clearance and hepatic function
• Factors linked to the genetic component
• Pharmacogenetics;
• Polypharmacy;
• the variability of the pharmacological response: individual, hyperreactivity and hyporeactivity, idiosyncrasy, drug allergy, tolerance, dependence.
• In-depth study of clinical trials to learn about the drug development phases with particular reference to the rules of randomized controlled trials necessary for an evidence-based therapeutic approach and to know how to critically read the experimental design and the results of a clinical trial and post- marketing.

Prerequisites and basic notions

Knowledge of the principles of general pharmacology and the main characteristics of pharmacology of main drug classes

Learning assessment procedures

Written and oral exam on the complete program.
The written test to ascertain knowledge consists of 30 questions, with multiple answers of which only one is correct, and - if the sufficiency of 18/30 is reached. - from 2) an oral interview to ascertain the critical knowledge for the possible improvement of the mark. For those who pass the written test, the oral test is optional.

Evaluation criteria

The exam will verify the acquisition of knowledge relating to clinical pharmacological research, the therapeutic properties of drugs, possible adverse reactions and the factors that influence the variability and personalization of the response in clinical use

The grade is out of thirty: maximum score is 30/30.

Criteria for the composition of the final grade

Oral exam with questions on clinical pharmacology and chemotherapy