Teaching code

4S01147

Credits

9

Coordinator

Cristiano Chiamulera

Language

Italian

Moodle Seminars 0

The teaching is organized as follows:

Learning outcomes

The aim of general part is to explain the students how drugs can effect patient’s health, without forgetting that drugs have both therapeutic, but also toxic effects. Furthermore, students should get a good knowledge of the interaction between drug and human organism, with particular reference to pharmacokinetics and pharmacodinamics. Overall objective of clinic part is to explain the students the main characteristics (mechanisms of action, pharmacokinetics, therapeutic use, adverse drug reactions, interactions) of the different pharmacological classes.

Program

Definition of drug and placebo; origin of drugs
Pharmacodynamics: drug-receptor interaction, transduction mechanisms and generation of drug effects
Pharmacokinetics: absorption, distribution, elimination and metabolism
Pharmacokinetics and biotransformations
Drug development, clinical trials
Pharmacogenetics and personalization of drug therapy
Drugs active on the Central and Peripheral Nervous System / Introduction to Neurochemistry
Drugs active on the Central and Peripheral Nervous System / Anti-PD
Drugs active on the Central and Peripheral Nervous System / Antiepileptics
Drugs active on the Central and Peripheral Nervous System / Opioid analgesics
Drugs active on the central and peripheral nervous system / Local anaesthetics
Drugs active on the autonomic nervous system / General overview
Drugs active on the Central and Peripheral Nervous System / Antipsychotics, Anxiolytics,
Drugs active on the Central and Peripheral Nervous System / Antidepressants
Drugs of Abuse
Drugs active on the respiratory system
Inflammation Pharmacology
Drugs active on the Cardiovascular System / Introduction to Antihypertensive Tx
Drugs active on the Cardiovascular System / Beta blockers + ACE-I
Drugs active on the Cardiovascular System / Calcium antagonists + Vasodilators
Drugs active on the Cardiovascular System / Antiangina + CHD
Drugs active on the Cardiovascular System / Antiarrhythmics and antilipemics
Anticoagulant, antithrombotics
NAO anticoagulant drugs, fibrinolytics
Antidiabetic drugs
Anti-ulcer drugs
EBM and Real World Evidence
Biotechnological drugs and for advanced therapies
Immunosuppressive drugs
Medicines for treatment of COVID19
Antineoplastic drugs
Antibiotic drugs
Antivirals and Antifungals
Food supplements
Bioequivalent and biosimilar drugs

Classification of drugs from the point of view of the National Health System.
International classification and epidemiology of ADRs: type A, B, C, D, E, F
Introduction to pharmacovigilance and spontaneous response reporting of adverse drug reactions
Pathogenetic mechanisms of ADRs, drugs interactions and ADRs and infections in special conditions (pregnancy, breastfeeding, elderly)
Health databases for post-marketing drug evaluation

Examination Methods

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MM: FARMACOLOGIA GENERALE E SPECIALE
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Oral exam on the content of the full programme. The exam will assess the acquisition of knowledge of basic and general principles, the specific features of the different drug classes in terms of mechanism of action, effects, safety and clinical use.
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MM: FARMACOVIGILANZA
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