Teaching code

4S01147

Credits

7

Coordinator

Gianluca Trifirò

Language

Italian

Scientific Disciplinary Sector (SSD)

BIO/14 - PHARMACOLOGY

Moodle Seminars 0

The teaching is organized as follows:

Learning objectives

Educational objective of the Course of Pharmacology is that students will acquire, through the analysis of the mechanisms of drug action, the ability to consider the drug as a tool to modulate cellular functions directly, or indirectly through activation of compensatory responses, and change the state of health of the patient. The student will be urged to make use of his/her knowledge of physiology and pathology in order to understand how the molecular and cellular mechanism of drug action determines the main therapeutic effect and the side- effects. The student will also be brought to understand that the size and quality of the effects, both desired and undesired, are a function of plasma concentration through the analysis of the pharmacokinetic, and as dose regimen should be adjusted according to the characteristics and liver - kidney functionality of the patient. The course will also teach the student, in an integrated vision, about the knowledge of the characteristics (mechanisms of action, kinetic, adverse reactions, therapeutic use) of different pharmacological classes, with particular reference to the application in dentistry.

Prerequisites and basic notions

Basic knowledge of principles of biochemestry, physiology and pathology

Program

Definition of drug and placebo; origin of drugs
Drug development, clinical trialsPharmacodynamics: drug-receptor interaction, transduction mechanisms and generation of drug effects
Pharmacokinetics: absorption, distribution, elimination and metabolism
Drugs active on the Central and Peripheral Nervous System / Opioid analgesics
Drugs active on the central and peripheral nervous system / Local anaesthetics
Drugs active on the Central and Peripheral Nervous System / Antipsychotics, Anxiolytics,
Drugs active on the Central and Peripheral Nervous System / Antidepressants
Inflammation Pharmacology
Drugs active on the Cardiovascular System / Introduction to Antihypertensive Tx
Drugs active on the Cardiovascular System / Beta blockers + ACE-I
Drugs active on the Cardiovascular System / Calcium antagonists + Vasodilators
Anticoagulant, antithrombotics, antiplatelet
Antidiabetic drugs
Anti-ulcer drugs
EBM and Real World Evidence
Biotechnological drugs and for advanced therapies
Antibiotic drugs
Food supplements
Bioequivalent and biosimilar drugs

Bibliography

Didactic methods

Interactives lectures of 2-3 hours with discussion of clinical cases whenever needed

Learning assessment procedures

The oral exam consists of a series of questions concerning the main parts of the program related to Pharmacodynamics, Pharmacokinetics and Pharmacotherapy, in particular on topics of relevance for the CdL. Some clinical cases will be briefly discussed to assess student's logical reasoning.
The student must demonstrate both the learning of the topics taught in class and the ability to expose them in a formal manner. The oral exam lasts about 30 minutes.

Evaluation criteria

At least two questions will be asked, and of these one will be related to general aspects of pharmacology and one will be realted to a drug class of interest for dentistry

Criteria for the composition of the final grade

The vote will be reported in XX/30 (at least 18/30 needed to pass the exam) based on completeness and accuracy of the answers

Exam language

Italiano