The present course has been designed to provide fundamental knowledge about pathophysiology, clinical, diagnostic classification and therapy of diseases of relevance of Internal Medicine with particular regard to those pathologies that may present clinical manifestations also at the level of the oral cavity and / or may be connected to the dental preservative treatment or maxillofacial surgery. It is also aimed at generating knowledge about the general prerequisites and criteria for the interpretation of laboratory tests based on the concepts of normality, reference intervals, analytic and biological intra- and inter-individual variability. At the end of the course students will be able to interpret the diagnostic value of laboratory tests, in terms of specificity, sensitivity, positive and negative predictive value. PRACTICAL ACTIVITY IN LABORATORY MEDICINE MODULE Educational goals. At the end of the course the student will: 1) Will know the basic principles of laboratory methodologies in the pre-analytical phase (sampling, treatment and storage of samples), analytical phase (principles and implementation of the most important laboratory techniques), and post-analytical phase (collection, processing and reporting of data, interpretation of results, quality control). PRACTICAL ACTIVITY IN INTERNAL MEDICINE MODULE Main objective: • To gain experience of patient history collection and patient clinical evaluation • To learn to assess main medical problems in internal medicine patients (acute and chronic diseases) • To learn the management of emergency in internal medicine such as acute respiratory failure, cardiac arrest DISEASES OF THE VISUAL SYSTEM At the end of this course the student should be able to: -Describe the anatomy and the physiopathology of the orbit and the adnexa (exophthalmos, inflammations and tumours of the orbit, pathology of the eyelids and of the lacrimal system, orbital trauma) -Describe the anatomy, physiopathology and the pathology of the conjunctiva, sclera, uvea, lens and posterior segment -Describe the physiopathology of the hydrodynamics of aqueous humour (Glaucoma) -Describe the physiopathology of the optic nerve and optic ways, eye refraction defects and of some pathologies of infancy. LABORATORY MEDICINE MODULE Educational goals. At the end of the course the student will: 1) Know the general prerequisites and criteria for the interpretation of laboratory tests based on the concepts of normality, reference intervals, analytic and biological intra- and inter-individual variability. Will be able to interpret the diagnostic value of laboratory tests, in terms of specificity, sensitivity, positive and negative predictive value. 2) Will know the pathophysiological meaning underlying the alterations of laboratory indexes and will integrate these alterations with the signs and symptoms clinically detected by the anamnesis and by the objective examination to arrive at a diagnostic interpretation of the most important clinical syndromes. 3) On the basis of the physiopathological and clinical significance of laboratory tests, the student will be able to understand the motivations of the exam requests, the logical operativity and the semiologic value of the individual tests in a typical clinical serie. INTERNAL MEDICINE MODULE The course is aimed to discuss and generate knowledge on internal medicine diseases, focusing on those with clinical manifestations involving mouth, neck/head. Pathophysiology, clinical presentation and complications of internal medicine disorders is part of the course.