Teaching code

4S000089

Teacher

Maria Romanelli

Credits

2

Language

Italian

Scientific Disciplinary Sector (SSD)

BIO/13 - EXPERIMENTAL BIOLOGY

Period

1 SEMESTRE PROFESSIONI SANITARIE dal Oct 1, 2021 al Dec 23, 2021.

Lessons timetable Moodle Seminars 0

To show the organization of the course that includes this module, follow this link:  Course organization

Learning outcomes

The course aims to provide the cognitive basis for understanding the contribution of biological macromolecules to the biological organization and functioning of structures of living organisms and the most important aspects of human biology. Teaching also seeks out the basic concepts of genetics, the most common genetic diseases, and their transmission modes. At the end of the course, the student must demonstrate knowledge and understanding of the basics of biology also concerning the health status of the human population.

Program

Synthetic program
General characteristics of living organisms.
- Life macromolecules: DNA, RNA, proteins.
- Cell structure and function: general characteristics, separation of subcellular components. The plasma membrane, cytoplasm, nucleus.
- The molecular basis of hereditary information. DNA characteristics, Watson and Crick model. DNA replication.
- Gene expression. Genetic code, transcription, translation. Gene expression regulation.
- Genetics. The composition of the genome.
- Mutations: types and effects. Spontaneous mutations. Mutagenesis by chemical and physical agents.
- Genome Organization.
- Chromatin: composition and structure.
- Chromosomes: structural patterns, karyotype, anomalies.
- The cell cycle. Mitosis
- Sexual and meiosis reproduction. Gametogenesis. Meiotic Errors: Aneuploids. The gene dosage and inactivation of the X chromosome, the determination of sex in the embryo.
- Genetics. Transmission of hereditary characters, Mendel's laws. Genotype and phenotype, autosomal and sex-related inheritance. Interpretation and discussion of genealogical trees. Genetics of blood groups. Methods of transmission of genetic diseases in humans, calculation of risks. Molecular Diagnosis.

Bibliography

Examination Methods

The assessment of learning outcomes envisages a written test to ensure knowledge of the topics under consideration.
The written test potentially covers all the topics listed in the program. It is articulated in groups of question-related to the main themes of the course (life macromolecules, cell biology, cell interactions, genetic information flow, Mendelian inheritance, human genetics). Items are formulated as multiple answer questions and open answer questions. The answer to each item requires knowledge of biological terminology, the ability to interpret genealogy trees, the ability to systematically connect knowledge of biology and genetic molecules, ability to describe and exemplify biological structures.
The examination will be validated with a minimum score of 18/30.
The overall evaluation of the answers to the questions is expressed in thirty/30.
To help the student to understand the contents and the formulation of the items, the examination tests submitted in the previous year will be discussed in the classroom with the students.