Teaching code

4S000090

Teacher

Ugo Moretti

Credits

2

Language

Italian

Scientific Disciplinary Sector (SSD)

BIO/14 - PHARMACOLOGY

Period

INF TN - 1° anno 2° sem dal Feb 1, 2019 al Apr 2, 2019.

Location

TRENTO

Lessons timetable Moodle Seminars

To show the organization of the course that includes this module, follow this link:  Course organization

Learning outcomes

Aim of the unit of General Pharmacology within the course of Application Physiopathology at Nursing is to give basics related to mechanism and use of drugs, with reference to pharmacodynamic, pharmacokinetic, pharmacoepidemiology and pharmacovigilance. Basic concepts in pharmacology are preparatory for the nurse’s role in the management and surveillance of pharmacological therapies an in patient’s education in the use of drugs. The general pharmacology module is preparatory to the study of each class of drugs, which starts from the anti-inflammatory and antibacterial drugs in this module and will be completed in clinical pharmacology module.

Program

Basic principles in Pharmacology and introduction to the drugs in the market
Definition of drug, active substance, pharmaceutical product, vehicle, eccipient, the placebo effect
Evaluation of the drugs’ efficacy: the randomized clinical trial
Different sources of drugs. How the drugs enter in the market
Bioequivalent and biosimilar drugs
The italian market for drugs. The drug prescription: fascia A e C, OTC and SOP drugs, different type of prescriptions
Indications and contraindications. The off-label use
How to measure the drug use: the DDD

Pharmacodynamic
Basic principles of the mechanism of action of drugs (drug’s receptor, drug-receptor interaction: agonism and antagonism)

Pharmacokinetic
Drug’s absorption. Main characteristics of different drug administration routes: advantages and disadvantages. The bioavailability of drugs. Food-drugs interactions
The drugs’ distribution in the body. Factors that can influence the drugs’ distribution: the blood-brain and placentar barriers
Characteristics of drug metabolism. Enzyme induction and inhibition
Drug’s clearance. Factors that may alter influence drug’s clearance
Definition and meaning of dose, maximum dose, daily dose, dosing, therapeutic index, clearance, half-life, peak blood levels, therapeutic range, toxic concentrations, accumulation
Relationship between plasma concentrations of drugs and their action
Factors to be taken into account in determining the dose of a drug, and in the case of repeated administrations, the dosing interval.
How to calculate pharmaceutical doses.

Pharmacotherapy
Basics of risk/benefit and cost/benefit analyses for drugs. Adverse drug reactions: mechanisms and risk factors. The spontaneous reporting system of adverse drug reactions: regulation and role for nurses



Antibacterial drugs: general issues and characteristics of the main classes of antibacterial drugs
Basics of antivirals and vaccines
Non-steroidal anti inflammatory drugs (NSAIDs)


Text book
Conforti, Cuzzolin, Leone, Moretti, Pignataro, Taglialatela, Vanzetta. Farmacologia per le professioni sanitarie, Sorbona Editore 2018

Examination Methods

Writing test with multiple choice questions

Teaching materials e documents

•   chemioterapia   (pdf, it, 5083 KB, 02/04/19)
•   FANS   (pdf, it, 6588 KB, 03/03/19)
•   Farmacocinetica   (pdf, it, 2566 KB, 13/02/19)
•   Farmacodinamica   (pdf, it, 1908 KB, 18/02/19)
•   Introduzione e mercato dei farmaci   (pdf, it, 3638 KB, 04/02/19)
•   reazioni avverse   (pdf, it, 970 KB, 26/02/19)
•   vaccini   (pdf, it, 4477 KB, 02/04/19)