Teaching code

4S000166

Teacher

Riccardo Montioli

Credits

2

Also offered in courses:

• Biomedical Sciences - BIOCHIMICA of the course Bachelor's degree in Orthopaedics Techniques

Language

Italian

Scientific Disciplinary Sector (SSD)

BIO/10 - BIOCHEMISTRY

Period

1 SEMESTRE PROFESSIONI SANITARIE dal Oct 3, 2022 al Dec 23, 2022.

Lessons timetable Moodle Seminars 0

To show the organization of the course that includes this module, follow this link:  Course organization

Program

PREPARATORY CHEMISTRY (basic knowledge required).
Atomic structure, atomic particles; quantum numbers, and orbitals; electronic configuration, periodic table and periodic properties of the elements; the chemical bond, molecules and ions; intermolecular forces; Solutions and concentration, acids and bases; pH and buffer solutions.
Organic chemistry notions: carbon atom properties; hybrid orbitals; organic compounds classification: functional groups; hydrocarbons; alcohols, ethers, thiols, amines, aldehydes and ketones; carboxylic acids, esters, anhydrides.
BIOCHEMISTRY
1. Constitutive elements of the living matter: polymeric structure of the biological macromolecules.
2. Protein structure and function: aminoacid classification, peptide bond, levels of protein structure; fibrous and globular proteins; hemoglobin and myoglobin: structure, function, factors influencing the oxygen bond; hemoglobin variants; enzymes: classification, role in the chemical reactions, co-enzymes, hints of enzyme kinetics, regulation of the enzymatic activity.
3. Bio-energetics: metabolism; chemical transformations in the cell; chemical equilibrium; spontaneous and non-spontaneous reactions of the metabolic reactions; ATP as “energy exchange coin”; biologically relevant redox reactions.
4. Carbohydrates structure and metabolism: mono- and disaccharides; polysaccharides; glycoconjugates; glycolysis and its regulation; gluconeogenesis; hints of the penthose phosphate pathway; synthesis of the glycogen.
5. Citric acid cycle and oxidative phosphorylation: mitochondria; acetyl-CoA synthesis; citric acid cycle control; respiratory chain and electron transport; ATP synthesis.
6. Lipids structure and metabolism: structural lipids and biological membranes; cholesterol; stock-reserve lipids; lipids digestion and fatty acid β-oxydation; keton bodies formation; hints of fatty acids biosynthesis.
7. Aminoacid metabolism: hints of gluco- and keto-forming aminoacids; transamination and oxidative deamination; the urea cycle.

Bibliography

Didactic methods

The teaching method used in this course is exclusively of the frontal type. The slides of the lessons will be made available on the moodle page of the course as a support to the study. Students are advised to choose a Biochemistry book among those indicated in the Bibliography of the University Library System.

Learning assessment procedures

Written exam consisting of 16 questions (8 fundamental and 8 deepening) with multiple choice and 1 open question

Evaluation criteria

To pass the test, students must demonstrate an adequate understanding of the knowledge of the topics in the program, the ability to reason and individually re-elaborate the concepts acquired. The ability to present their arguments in a critical, precise, concise manner and with appropriate scientific language will also be assessed. The mark is expressed in thirtieths and the test is considered passed if the evaluation obtained is greater than or equal to 18 thirtieths.

Exam language

Italiano