Studying at the University of Verona
Here you can find information on the organisational aspects of the Programme, lecture timetables, learning activities and useful contact details for your time at the University, from enrolment to graduation.
Study Plan
The Study Plan includes all modules, teaching and learning activities that each student will need to undertake during their time at the University.
Please select your Study Plan based on your enrollment year.
1° Year
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2° Year activated in the A.Y. 2016/2017
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3° Year activated in the A.Y. 2017/2018
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Legend | Type of training activity (TTA)
TAF (Type of Educational Activity) All courses and activities are classified into different types of educational activities, indicated by a letter.
Diagnostic methodologies for Biochemistry and Molecular Biology - BIOTECNOLOGIE RICOMBINANTI (2017/2018)
Teaching code
4S000351
Teacher
Credits
1
Language
Italian
Scientific Disciplinary Sector (SSD)
BIO/12 - CLINICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY
Period
TLB LEZ 3ANNO 1 SEM 16-17 dal Oct 2, 2017 al Dec 7, 2017.
Location
VERONA
To show the organization of the course that includes this module, follow this link: Course organization
Learning outcomes
The course aims to make students understand the basic stages of the birth of modern biotechnologies and the current applications of recombinant biotechnology in biomedical and pharmaceutical fields. We will discuss issues of a scientific, ethical and biological nature. The course also aims to provide an updated view of recombinant techniques including techniques for reproductive and therapeutic cloning, technic for the reproduction of recombinant drugs.
Program
1) History of modern Biotecnology. The Reproductive cloning. The Therapeutic cloning. Critical review of two fundamental scientific works: 1) Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH.Viable offspring derived from fetal and adult mammalian cells.Nature. 1997 Feb 27;385(6619):810-3.
2) Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, Hubschman JP, Davis JL, Heilwell G, Spirn M, Maguire J, Gay R, Bateman J, Ostrick RM5, Morris D, Vincent M, Anglade E, Del Priore LV, Lanza R. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies. Lancet. 2015 Feb 7;385(9967):509-16.
2) Cloning vectors. Role of DNA ligase restriction enzymes, alkaline phosphatase. Plasmids. Methods for introducing DNA into a host cell: transformation and transfection. Vectors selection and isolation.
3) Transgenic animals. Gene transfer techniques: irestriction-enzyme-mediated integration (REMI), DNA microinjection, Sperm-mediated gene transfer, Retrovirus-mediated gene transfer. Gene targeting. knockout mice.
4) Clinical applications of recombinant drugs. Human recombinant TSH. production technique, commercial products, pharmacokinetic properties, approval for clinical use. Use in the diagnosis and follow-up of differentiated thyroid carcinoma
5) Clinical applications of recombinant drugs. Recombinant erythropoietin: production technique, commercial products, pharmacokinetic properties, approval for clinical use. Recombinant insulin: production technique, pharmacokinetic properties, clinical use, commercial products.
| Author | Title | Publishing house | Year | ISBN | Notes |
|---|---|---|---|---|---|
| Lizabeth A. Allison | Fundamental Molecular Biology | Blackwell publishing | 2002 | 978-1-4051-0379-4 |
Examination Methods
Oral exam
