Docente

Patricia Lievens

Referente

Patricia Lievens

Crediti

2

Lingua di erogazione

English

Frequenza alle lezioni

Scelta Libera

Sede

VERONA

Moodle Seminari 0

Obiettivi di apprendimento

The proposed teaching activity has the objective to familiarize students with the world of Tyrosine Kinase Receptors, key players in signal transduction and cellular fate. The major focus will be on Fibroblast Growth Factor Receptor 3 (FGFR3), a member of the FGFR1-4 subfamily, associated with several forms of chondrodysplasias and tumors.

Prerequisiti e nozioni di base

No specific prerequisites requested

Programma

The course will be declined as it follows: 1) Introduction to RTKs structure and function mediated by reversible post-translational phosphorylation; 2) Description of FGFR3 roles in skeletal development and the diseases associated with FGFR3 germinal mutations; 3) Experimental approaches to investigate FGFR3 function in health and disease, comprising protein structure studies and the use of cellular and animal models suitable to recapitulate human bone defects; 4) History of strategies developed to address therapy for chondrodysplasias and current state of the art; 5) Short overview on tumors associated with FGFR3 somatic mutations.

Bibliografia

Modalità didattiche

Frontal lessons

Modalità di verifica dell'apprendimento

No assessment test will be provided

Valutazione

NA

Criteri di composizione del voto finale

NA

Lezioni Programmate