Teaching code

4S000332

Credits

4

Coordinatore

Cristiano Chiamulera

Language

Italian

Moodle Seminars

The teaching is organized as follows:

Learning outcomes

MODULO FARMACOLOGIA GENERALE Obiettivi formativi: Fornire allo Studente i fondamenti della disciplina farmacologica e gli strumenti conoscitivi applicativi necessari per lo svolgimento del ruolo del tecnico di laboratorio nel controllo delle terapie farmacologiche.

MODULO FARMACOTOSSICOLOGIA Obiettivi formativi: Introdurre gli studenti al concetto di Monitoraggio Terapeutico dei Farmaci (TDM) applicato alle maggiori classi di farmaci e la tossicità da metalli e solventi.

MODULO METODI E TECNICHE DI LABORATORIO IN FARMACIA Obiettivi formativi: Lo studente al termine del corso deve conoscere: • i principi fondamentali sui test di screening per la determinazione di diverse droghe d’abuso sulle urine (test immunologici e procedure analitiche in HPLC) • le tecniche di utilizzo nei Laboratori per il monitoraggio di farmaci immunosopressori e il monitoraggio dei farmaci più usati • Cenni su farmaci antiblastici e gestione in laboratorio.

Program

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MM: GENERAL PHARMACOLOGY
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General pharmacology Pharmacodynamics Drug receptor interaction, potency and efficacy, clinical effectiveness, competition and antagonism. Receptor: definition, mechanisms of action, receptor adaptation. Pharmacokinetics Absorption and the different routes of drug administration. Distribution and plasma levels. Metabolism, especially liver: induction, inhibition, drug interactions. Elimination. Concepts and pharmacokinetic parameters: dosage, maximum dose, daily dose, dosage, clearance, half-life, plasmatic peak, therapeutic range, toxic concentrations. Pharmacotherapy Definitions of drug, placebo, medicinal product, packaging, pharmaceutical formulations. The process of research and drug development. Critical issues related to the use of drugs: tolerance, interactions, compliance, self prescription. SPECIAL PHARMACOLOGY Fundamentals on drugs and drug addiction.
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MM: PHARMACO-TOXICOLOGY
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Pharmacokinetics: absorption and administration routes. Bioavailability, kinetic differences related to the administration route. Distribution. Metabolism. Elimination and variability factors Pharmacodynamics: receptors, agonist and antagonistic drugs, dose-response curve. Drug safety. Therapeutic Index. Drugs adverse reactions: classification Therapeutic Drug Monitoring. Interpretation of measurement of serum levels Antibiotics: brief description of the major classes of antibiotics: antibiotics submitted to TDM. Antifungal drugs. Antiviral drugs Antiepileptic drugs: mechanism of action, toxicity and interactions. Phenytoin, carbamazepine, barbiturates, etosuccimmide, valproic acid, benzodiazepines and lithium. Antiasthmatic drugs: mechanism of action, toxicity and interactions of beta2 receptor antagonists, theophylline and xanthine Immunosuppressant drugs: mechanism of action, toxicity and interactions. Methotrexate, Cyclosporine, Tacrolimus, Sirolimus, Mycophenolic acid Coagulation Cascade and coagulation drugs: Coumarin, Heparin. Coagulation parameters during anticoagulant therapy. Digoxin: mechanism of action, toxicity and interactions
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MM: METHODS AND TECHNIQUES IN PHARMACY LABORATORY
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Toxicology: general, dose - response relationship, drug classification most used. Therapeutic Drug Monitoring, Analysis methods of medication (Interpretation of the measurements of plasma concentrations. Abnormal findings in chemical and clinical analysis : influence of biological variability and pharmacological treatment of the following drugs : methotrexate , cyclosporine , Tracrolimus). Security procedures for the preparation and safe disposal of anticancer drugs

Bibliography

Examination Methods

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MM: GENERAL PHARMACOLOGY
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Written test. The test is based on multiple choice test.
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MM: PHARMACO-TOXICOLOGY
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Written test. The test is based on multiple choice test.
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MM: METHODS AND TECHNIQUES IN PHARMACY LABORATORY
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Written test. The test is based on multiple choice test.