Teaching code

4S02742

Credits

4

Coordinatore

Flavia Bazzoni

Language

Italian

Moodle Seminars

The teaching is organized as follows:

Learning outcomes

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MM: FARMACOLOGIA
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Provide to students the basic knowledge necessary to understand the mechanisms of action(s) of the drugs and predict and manage their therapeutic and toxic effecs
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MM: MICROBIOLOGIA
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Basic concepts of the world of microorganisms. Major differences among bacteria, viruses, fungi, protozoa and their role as agents of infectious diseases. Characteristics of the various microorganisms and their structures
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MM: PATOLOGIA GENERALE
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The student must acquire knowledge of the pathogenetic mechanisms controlling and characterizing the principal human pathologies. The main training objectives are: • understanding of the mechanisms of cellular and molecular damage • understanding of the pathogenetic processes • study of the mechanisms responsible for the recovery of the healthy state .

Program

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MM: FARMACOLOGIA
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Analysis of drug/receptor interaction and the generation of drug effect(s); know the terminology related to drug use, the methodologies of drug identification and clinical development. Analysis of the pharmacokinteic properties of drugs applied to patient treatment with detailed knowledge and understanding of : 1- drug absorption with emphasis on differences between routes of administration;2- drug distribution and elimination; 3- drug metabolism ; 4- quantitative approach to pharmacokinetics and the definition of a therapeutic regimen
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MM: MICROBIOLOGIA
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• Aims of microbiology. Classification of microorganisms in the world of the living. • Structure and characteristics of fungi and protozoa. • The architecture of the bacterial cell: differences between gram positive and gram negative bacteria. • Pathogenicity and virulence of the bacteria. Bacteria pathogens conventional and opportunists bacteria • Mechanisms of pathogenic bacteria: exotoxins and endotoxin bacterial • Bacteria of clinical interest: streptococci, staphylococci, enterobacteri, neisserie. Batteria anaerobe obligate and spore-forming (clostridia) • Virus: architecture, classification and mechanisms of replication. • Mechanisms of pathogenic viruses. infections localized, generalized, silent, persistent, slow, latent. • The Herpesviruses: HSV-1/2, VZV, EBV, CMV. • The Retrovirus: HIV1 and 2 • Virus causes of hepatitis: HAV, HBV, HCV, HDV. • Flue virus: Orthomyxovirus • Polioviruses
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MM: PATOLOGIA GENERALE
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1. Introduction General concepts Homeostasis. Pathogenesis Etiology Glossary 2. Cellular pathology Pathogenesis of hypoxia, ischemia and oxidative stress. Cellular death: apoptosis and necrosis molecular markers of cell death 3. The innate immune response Mononuclear phagocytes: features and functions Acute inflammation: vascular changes and cellular events Inflammatory exudate: characteristics and functions Chemical Mediators and Regulators of Inflammation Leucocyte recruitment Leukocyte effector mechanisms ( phagocytosis, Killing and degradation of phagocytosed Microbes) Systemic effects of inflammation Outcomes of acute inflammation: Chronic inflammation Resolution: Regeneration and repair. Scarring 4. Basic immunology Innate and adaptive immunity: general concepts Cells and tissues of the immune system Overview of normal immune responses Cellular and humoral immunity. Vaccines 5. Pathological changes of cellular differentiation and proliferation Neoplasia (general concepts) Morphological, molecular and functional features of the neoplastic cell Nomenclature Molecular bases of carcinogenesis: oncogenes and oncosuppressors

Bibliography

Examination Methods

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MM: FARMACOLOGIA
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Written exam with multiple choice questions
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MM: MICROBIOLOGIA
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Questions of multiple choice or short open questions + interview (when needed).
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MM: PATOLOGIA GENERALE
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written test