Teaching code

4S000089

Teacher

Elio Maria Liboi

Credits

2

Language

Italian

Scientific Disciplinary Sector (SSD)

BIO/10 - BIOCHEMISTRY

Period

1 SEMESTRE PROFESSIONI SANITARIE dal Oct 1, 2021 al Dec 23, 2021.

Lessons timetable Moodle Seminars 0

To show the organization of the course that includes this module, follow this link:  Course organization

Learning outcomes

To transmit the main chemical principles to allow comprehension of the mechanisms that control matter interaction. To explain macromolecules organization and the principle of metabolism. To understand factors that regulate the main metabolic pathways. Emphasis will be on physiological and pathological processes associated to the main biochemical functions.

Program

Molecules: water. Properties and interactions in water.
Solutions: definitions and concentrations (Molarity), osmosis.
Buffer, pH.
Chemical reactions: red/ox.
Thermodynamic: Free energy (G), energetic potential of ATP, coupled reactions.

Biochemistry

Proteins: amino acids, peptide bound. Protein structures.
Post translational modifications. Quality control for secreted proteins.
Enzymes: kinetic, mechanism of action. Enzymatic inhibition. Allosteric regulation.
Nucleic acids: nucleotides, DNA, RNA
Sugars: simple and complex sugars. sugar bond, polysaccharides (starch and glycogen).
Glycoproteins: blood groups.
Membranes: properties, phospholipids, double layer.
Lipids: fatty acids, cholesterol.

Metabolism.
general principles, regulations, hormones, vitamins.
Sugar metabolism: glycolysis, regulations, alcohol fermentation, lactic fermentation. Pentose cycle.
Citric acid cycle: oxidative phosphorylation, ATP synthase
Gluconeogenesis.
Fatty acid metabolism: fatty acid digestion, beta oxidation, ketone bodies.
Fatty acid synthesis
Protein metabolism: transamination. Urea cycle.
Protein biosynthesis.

Bibliography

Examination Methods

written test multiple Choice