Learning objectives

The main objective is to provide learning tools for this new frontier of science represented by the interpretation of the role of the modulation of gene expression in mechanisms regulating the blood coagulation balance. The role of epigenomics in regulating the pathophysiology of the hemostatic system. Specific training objectives of the course are: - to understand the genetic and epigenetic mechanisms, including in particular, DNA methylation, post-transcriptional histone modifications, through which environmental and pathophysiological factors influence the ways in which they interact with the structure of the genome and with the mechanisms of gene expression; - learn the specific cellular sites of interaction with the gene expression mechanisms for protein synthesis; - acquire knowledge of the main molecular biology methodologies used to study genomics and epigenomics including gene-specific and genome-wide approaches.

Prerequisites and basic notions

Knowledge of general notions of biology, biochemistry, molecular biology in the human eukaryotic cell and of the basic notions of genetics, genomics and epigenomics.

Program

- physiological and pathophysiological bases of epigenetics, epigenetics and transcriptomics - pathophysiology of the blood coagulation cascade - scientific evidence from the literature of genes and blood coagulation pathways regulated by epigenetic mechanisms - main methodologies using advanced and up-to-date molecular biology techniques used for the approach to genetics, transcriptomics and nutriepigenomics with innovative gene-specific and genome-wide approaches

Bibliography

Didactic methods

- seminar and outline of methods for interpreting scientific works

Learning assessment procedures

- test with an interactive oral interview based on the topics covered

Assessment

presence at seminar activities and resourcefulness with the proposed in-depth activities

Criteria for the composition of the final grade

jointly with the other teachers of the course

Scheduled Lessons