Training and Research

Credits

3

Language

English

Class attendance

Free Choice

Location

VERONA

Learning objectives

Acquisition of advanced techniques for the analysis of biomedical data.

Acquire essential knowledge of tumor genomics.

Understand the architecture of precision oncology systems.

Learn methods and application software for processing, managing, and analyzing clinical and genomic data.

Practically apply sequencing data analysis using the R language.

Prerequisites and basic notions

Knowledge of omics analysis and programming skills are required.

Program

Introduction to Cancer:
Hallmarks of cancer
Case study: Multiple myeloma
Overview of cancer therapy
Introduction to Precision Oncology:
Rationale and objectives
Progress and milestones
Clinical trials and regulatory considerations
Limitations and future prospects
High-Throughput Sequencing Technologies:
DNA sequencing
RNA sequencing
Architecture of a Precision Oncology Platform:
Designing and implementing a precision oncology workflow
From raw data to actionable insights
Pre-Processing of Sequencing Data and Quality Control:
Quality control measures
Data preprocessing steps
DNA Sequencing Analysis:
Read alignment
Mutation calling: single-nucleotide variations (SNVs) and short indels
Copy number alterations
Genomic metrics and interpretation
RNA Sequencing Analysis:
Read alignment: reference-based vs. pseudo-alignment
Gene expression quantification
Gene expression profiling
Data normalization techniques
Differential expression analysis and biomarker identification
Functional analysis (gene set and pathway analysis)
Gene fusion detection
Survival Analysis:
Kaplan-Meier estimation
Cox proportional hazards model
Stratified analysis and interpretation
Intra-Tumor Heterogeneity: Modeling and Tumor Evolution:
Clonal evolution
Computational modeling techniques
Drug Repurposing: Methods and Applications:
Computational drug repurposing methods
Case studies and success stories
Data Annotation, Interpretation, and Prioritization:
Integrating clinical data
Annotation tools and databases
Prioritization algorithms
Precision Medicine Reports:
Structure and components of a precision medicine report
Communicating findings to clinicians
Case Study: Precision Medicine in Multiple Myeloma:
Detailed case study
Integrative analysis
Clinical impact

Didactic methods

Theory and practice

Learning assessment procedures

Presentation of a report

Students with disabilities or specific learning disorders (SLD), who intend to request the adaptation of the exam, must follow the instructions given HERE

Assessment

The correctness of the methodology and analyzes conducted, the clarity of exposition and the student's autonomy will be evaluated.

Criteria for the composition of the final grade

The average of each rating point.

PhD school courses/classes - 2024/2025

Please note: Additional information will be added during the year. Currently missing information is labelled as “TBD” (i.e. To Be Determined).

1. PhD students must obtain a specified number of CFUs each year by attending teaching activities offered by the PhD School.
First and second year students must obtain 8 CFUs. Teaching activities ex DM 226/2021 provide 5 CFUs; free choice activities provide 3 CFUs.
Third year students must obtain 4 CFUs. Teaching activities ex DM 226/2021 provide 2 CFUs; free choice activities provide 2 CFUs.
More information regarding CFUs is found in the Handbook for PhD Students: https://www.univr.it/phd-vademecum

2. Registering for the courses is not required unless explicitly indicated; please consult the course information to verify whether registration is required or not. When registration is actually required, instructions will be sent well in advance. No confirmation e-mail will be sent after signing up. Please do not enquiry: if you entered the requested information, then registration was silently successful.

3. When Zoom links are not explicitly indicated, courses are delivered in presence only.

4. All information we have is published here. Please do not enquiry for missing information or Zoom links: if the information you need is not there, then it means that we don't have it yet. As soon as we get new information, we will promptly publish it on this page.

Summary of training activities

Teaching Activities ex DM 226/2021: Linguistic Activities

Teaching Activities ex DM 226/2021: Research management and Enhancement

Teaching Activities ex DM 226/2021: Statistics and Computer Sciences

Teaching Activities: Free choice

Course lessons
PhD Schools lessons

Loading...

Guidelines for PhD students

Below you will find the files that contain the Guidelines for PhD students and rules for the acquisition of ECTS credits (in Italian: "CFU") for the Academic Year 2023/2024.

Documents

Title Info File
File pdf Dottorandi: linee guida generali (2024/2025) pdf, it, 104 KB, 29/10/24
File pdf PhD students: general guidelines (2024/2025) pdf, en, 107 KB, 29/10/24