The central nervous system (CNS) is dynamically regulated by the entire body’s physiological and pathological conditions. Recent studies reveal that these conditions often change and involve changes introduced into the gut microbiota, which directly modulate the CNS. This bidirectional interaction between the gut microbiota and CNS, also known as the gut-brain axis, plays a major role in the pathogenesis of many neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and Huntington's disease (HD).
During this lesson, the students will learn the bases of this axis and the microbiota-mediated mechanisms that modulate the brain's functioning. Recent articles exploring microbiota intervention in disease models and humans will be used as examples. Finally, we will discuss how studying microbiota may help develop interventions and clinical treatments for these diseases.

Prerequisites and basic notions

there are none

Program

The central nervous system (CNS) is dynamically regulated by the physiological and pathological conditions of the entire body. Recent studies reveal that these conditions often change and involve changes introduced into the gut microbiota, which directly modulate the central nervous system. This bidirectional interaction between the gut microbiota and the central nervous system, also known as the gut-brain axis, plays an important role in the pathogenesis of many neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD), sclerosis lateral amyotrophic disease (ALS), multiple sclerosis (MS) and Huntington's disease (HD). During this lesson students will learn the basics of this axis and the microbiota-mediated mechanisms that modulate the functioning of the brain. Recent articles exploring the intervention of the microbiota in disease models and humans will be used as examples. Finally, we will discuss how studying the microbiota can help develop clinical interventions and treatments for these diseases.

Bibliography

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Learning assessment procedures

not expected

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PhD in Inflammation, Immunity and Cancer

PhDs

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PhD Programme Courses/classes

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Gut microbiota in neurodegeneration (2022/2023)

Learning objectives

Prerequisites and basic notions

Program

Bibliography

Learning assessment procedures

Assessment

Criteria for the composition of the final grade

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