Training and Research
PhD Programme Courses/classes - 2022/2023
Alternative Cancer Therapies
Credits: 0,5
Language: Italian
Analysis of single-cell transcriptomics
Credits: 0,5
Language: Italian
Teacher: Eleonora Terrabuio
Presentazione dell'antigene: la chiave per l'attivazione dei linfociti T.
Credits: 0,5
Language: English
Approaches to the study of intra-tumor heterogeneity
Credits: 0,5
Language: Italian
Teacher: Vincenzo Corbo
Astrocytes in the Central Nervous System
Credits: 0,5
Language: Italian
Teacher: Vittorina Della Bianca
Cancer-immunoediting
Credits: 0,5
Language: Inglese
Teacher: Francesco De Sanctis
Cancer-immunoediting
Credits: 0,5
Language: IDONEITA' BASATA SULLA FREQUENZA
Teacher: Stefano Ugel
Immunologia dei tumori
Credits: 0,5
Language: Italian
Teacher: Vincenzo Bronte
Common immune mechanisms in Alzheimer's disease and multiple sclerosis
Credits: 0,5
Language: Italian
Teacher: Gabriela Constantin
Epigenetic and transcriptional regulation of inflammatory responses
Credits: 0,5
Language: inglese
Teacher: Nicola Tamassia
Flow Cytometry: principles, practice, and advanced techniques
Credits: 0,5
Language: Italian
Teacher: Andrea Mafficini
From pathology to genomics and back
Credits: 1
Language: Italian
Teacher: Andrea Mafficini
Genome regulation by long non coding RNA
Credits: 0,5
Language: non applicabile
Teacher: Flavia Bazzoni
Gut microbiota in neurodegeneration
Credits: 0,5
Language: inglese
Teacher: Elena Zenaro
Mechanisms of cancer cell adaptation to microenvironmental changes
Credits: 0,5
Language: Italian
Teacher: Vincenzo Corbo
La cellula microgliale nelle malattie neurodegenerative
Credits: 0,5
Language: Inglese
Teacher: Enrica Caterina Pietronigro
Neutrophil extracelluar traps (NETs): ruolo fisiologico e patologico
Credits: 0,5
Language: non ci sono prove
Teacher: Patrizia Scapini
Modelli 2D/3D di organoidi intestinali : stato dell'arte ed applicazioni
Credits: 0,5
Language: english
Teacher: Claudio Sorio
Autoimmune pancreatitis
Credits: 0,5
Language: Italian
Teacher: Giuseppe Zamboni
PD-L1 nel cancro
Credits: 0,5
Language: Italiano e Inglese
Teacher: Anna Caliò
Precision Functional Genomics in Cancer
Credits: 0,5
Language: Italian
Teacher: Vincenzo Corbo
Le tirosin fosfatasi nella regolazione delle funzioni leucocitarie
Credits: 0,5
Language: English
Teacher: Alessio Montresor
Radiomics in Oncology
Credits: 0,5
Language: English
Teacher: Riccardo De Robertis Lombardi
Small GTPases of the rho family
Credits: 0,5
Language: Italian
Teacher: Carlo Laudanna
Colpire il microambiente tumorale per migliorare l'efficacia dell'immuno terapia
Credits: 0,5
Language: Inglese
Teacher: Francesco De Sanctis
The blood-brain barrier during physiological and pathological conditions (Part II)
Credits: 0,5
Language: Italian
Teacher: Gabriela Constantin
The blood-brain barrier under physiological and pathological conditions (Part I)
Credits: 0,5
Language: Italian
Teacher: Gabriela Constantin
Le dinamiche del sistema immunitario
Credits: 0,5
Language: Italian
Teacher: Barbara Rossi
ph D Course in Inflammation, Immunity and Cancer
Credits: 0,5
Language: English
Teacher: Marco Antonio Cassatella
Tumor Organoids as preclinical model for drug discovery and sensitivity
Credits: 0,5
Language: Italian
Teacher: Vincenzo Corbo
Le tirosin fosfatasi nella regolazione delle funzioni leucocitarie (2022/2023)
Teacher
Referent
Credits
0.5
Language
English
Class attendance
Free Choice
Location
VERONA
Learning objectives
The objective of the course is to provide students with basic knowledge relating to the molecular mechanisms of leukocyte recruitment which represents a fundamental event in various pathological conditions of an inflammatory or neoplastic nature. Specifically, the lesson will cover in detail the role of integrin activation in this process. Integrin activation, which manifests itself as an increase in the affinity of integrins for ligands, is regulated by complex molecular mechanisms of signal transduction, which involve kinases and phosphatases. Phosphorylation constitutes a fundamental mechanism for signal transduction and the balance of enzymatic activity between kinases and phosphatases determines the levels of protein phosphorylation and regulates their activation. Protein phosphatases are divided based on substrate specificity and are grouped into tyrosine phosphatases (PTPs) and serine-threonine phosphatases (PSTPs). The PTPRG tyrosine phosphatase belongs to the group of receptor-like tyrosine phosphatases (RPTPs), with phosphatase activity in the intracellular domain (ICD). Data produced by the research laboratories coordinated by the course teachers have recently revealed that the activation of PTPRG prevents, in human monocytes, integrin adhesion and activation induced by chemotactic factors and inhibits the transition of LFA-1 towards high affinity state, through dephosphorylation of the JAK2 kinase. Furthermore, in human B lymphocytes from healthy donors and patients with chronic lymphocytic leukemia (CLL), PTPRG activation prevents integrin adhesion and activation, via inhibition of JAK2 and BTK kinases. Finally, PTPRG activation induces apoptosis selectively in leukemic cells, while B lymphocytes from healthy donors remain viable, with the possibility therefore that PTPRG may function as a tumor suppressor gene in CLL.
Prerequisites and basic notions
Knowledge of the English language
Program
- Classification of phosphatases; - Description of the activity of phosphatases; - Description of the main classes of tyrosine phosphatases; - Description of the tyrosine phosphatase PTPRG and its role in pathogenetic contexts.
Didactic methods
Frontal lesson
Learning assessment procedures
Not expected.
Assessment
The evaluation is based on mandatory and active presence in the lesson.
Criteria for the composition of the final grade
No final grade expected.
PhD school courses/classes - 2022/2023
Faculty
guido.martignoni@univr.it
sara.pilotto@univr.it
+39 045 802 7125
PhD students
Spoto Flavio
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Guidelines for PhD students
Below you will find the files that contain the Guidelines for PhD students and rules for the acquisition of ECTS credits (in Italian: "CFU") for the Academic Year 2023/2024.
