Studying at the University of Verona
Here you can find information on the organisational aspects of the Programme, lecture timetables, learning activities and useful contact details for your time at the University, from enrolment to graduation.
Study Plan
This information is intended exclusively for students already enrolled in this course.If you are a new student interested in enrolling, you can find information about the course of study on the course page:
Laurea magistrale in Molecular and Medical Biotechnology - Enrollment from 2025/2026The Study Plan includes all modules, teaching and learning activities that each student will need to undertake during their time at the University.
Please select your Study Plan based on your enrollment year.
1° Year
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Two courses among the followingThree courses among the followingOne course among the followingOne course among the following2° Year activated in the A.Y. 2023/2024
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| Modules | Credits | TAF | SSD |
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Two courses among the followingThree courses among the followingOne course among the followingOne course among the following| Modules | Credits | TAF | SSD |
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| Modules | Credits | TAF | SSD |
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2 courses among the following ("BIOTECHNOLOGY IN NEUROSCIENCE" 1ST YEAR; "CLINICAL PROTEOMICS" 1ST and2ND YEAR; the other courses 2nd year only)Legend | Type of training activity (TTA)
TAF (Type of Educational Activity) All courses and activities are classified into different types of educational activities, indicated by a letter.
Protein misfolding and human diseases (2022/2023)
Teaching code
4S003664
Academic staff
Coordinator
Credits
6
Language
English
Scientific Disciplinary Sector (SSD)
BIO/10 - BIOCHEMISTRY
Period
Semester 2 dal Mar 6, 2023 al Jun 16, 2023.
Learning objectives
This course aims to provide information on conformational disease, protein quality control system, chaperone,inherited disorders. In particular, students will gain familiarity with principles of protein misfolding; protein misfolding disease; medical aspects of disease: diagnosis and current therapies
Prerequisites and basic notions
Basic knowledge of biochemistry and molecular biology and genetics. There are no prerequisites for taking the exam
Program
Protein folding and misfolding
Cellular Strategies of Protein Quality Control (PQC)
Molecular chaperones
Structure and Function of the HSP90 machinery
The amyloid state
Tau Proteins
Molecular Pathogenesis of Alzheimer Disease
Techniques for Monitoring Protein Misfolding and Aggregation
Antibodies and protein misfolding
α-Synuclein misfolding and aggregation in Parkinson’s disease
Molecular Pathogenesis in Huntington’s Disease
Superoxide Dismutase in Familial ALS
α1-antitrypsin deficiency
Prions and prionoids
The 26S Proteasome
Targeting the 26S Proteasome
Strategies that target protein aggregation
Bibliography
Didactic methods
Classroom lessons with the support of power-point slides. Students are provided with the teaching materials for the lessons in advance
Learning assessment procedures
Written test.
The exam consists of 5 open questions on course topics.
The student will choose three out of five questions, he/she will be allowed to answer both in Italian and in English.
The maximum time of the test is two hours
Evaluation criteria
In-depth knowledge of the topics discussed in the written answers is assessed
Criteria for the composition of the final grade
The vote is expressed in thirtieths. Each written answer is assigned 0 to 10 points
Exam language
Inglese
