Teaching code

4S007272

Credits

5

Coordinatore

Claudio Sorio

Moodle Seminars

The teaching is organized as follows:

Program

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MM: MEDICINA INTERNA E TERAPIA MEDICA
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ENDOCRINOLOGY – Diabetes (pathophysiology , morbidity and mortality, acute and chronic complications , therapy), GH pathologies , thyroid diseases, Adrenal gland diseases. HEMATOLOGY : Anemia
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MM: FARMACOLOGIA
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Drug development and clinical trials Terminology related to drug use, the methodologies of drug identification and clinical development. Adverse reactions: classification and reporting Pharmacovigilance Analysis of drug/receptor interaction and the generation of drug effect(s). Analysis of the pharmacokinetic properties of drugs applied to patient treatment with detailed knowledge and understanding of: 1- drug absorption with emphasis on differences between routes of administration;2- drug distribution and elimination; 3- drug metabolism; 4- quantitative approach to pharmacokinetics and the definition of a therapeutic regimen Mechanisms of action, classification, therapeutic effects and adverse reactions and clinical uses of anti-inflammatory drugs and analgesics such as paracetamol and opioids Mechanisms of action of drugs active on the neuromuscular system Mechanisms of action, classification, therapeutic effects and adverse reactions and clinical uses of anti-Parkinson drugs
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MM: MICROBIOLOGIA
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• Microbiology introduction • Bacteriology: • bacterial cells and spore structure and functions. • Bacterial replication • Bacterial pathogenesis • Virology: • Virus structure and composition • Viral replication • Viral infections • Way of infections transmission and preventions.
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MM: PATOLOGIA GENERALE
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Introduction to pathology • Cell homeostasis and alterations at the cell and organism levels • The concept of biochemical lesion and subcellular localization • Alteration of cell homeostasis: adaptation, necrosis, apoptosis, restoration of cell damage • Examples of cell adaptation: alterations of cells status and differentiation Causes of disease and mechanisms of cell damage • General classification of the causes of disease: genetic (example: cystic fibrosis), environmental, multifactorial (example: atherosclerosis), chemical (example: alcohol), radiation, free radicals • Mechanisms of healing Oedema: pathogenesis and classification Introduction to immunology and immunological damage • Innate and acquired immunity: description of leukocytes involved and general mechanisms • General features: antigen presentation, lymphocyte subclasses, complement • MHC ad transplants • Blood groups • Mechanisms of immuological damage: anafilaxis, complement activation, role of antibodies and Fc receptor, cell-dependent cytotoxicity Inflammation • Role of blood vessels in inflammation • Cells involved in inflammation • Classification of inflammatory response based on prevalent features: erithematous, serous, fibrinous, purulent, necrotic-haemorragic • Differences among acute and chronic inflammation • Cytokines and their role in the regulation of the inflammatory response Neoplasia • Differences among benign and malign neoplasms • Properties of neoplastic cells: growth, invasion and differentiation • General classification: epithelial, mesenchimal, neuroectodermal and germinal, hemopoietc cells neoplasms • Natural history of neoplasia: precancerous lesions, carcinoma in situ, metastasis. Preferential localization. TNM score. • Molecular basis of neoplastic transformation: oncogenes and tumor suppressor genes. Mechanisms of activation/inhibition. • Cancer etiology: physical, chemical and biological • Mechanism of damage: compression, paraneoplastic syndromes, cachexia • Cancer biomarkers and their clinical relevance

Bibliography

Examination Methods

Oral or written or combination thereof. Students will be informed before examination.