Learning objectives

The course is concerned with describing the basic principles of neuronal communication processes in creating circuits and systems, and the interactions that elicit the brain functions underlying behavior. In addition, special emphasis will be placed on the possibility of modulating neuronal and circuit activity through invasive and noninvasive techniques. To this end, the main mechanisms underlying techniques for recording neuronal activity and their modulation will be described, focusing more on transcranial electrical (TES) and magnetic stimulation (TMS) modalities. Topics covered include morphological and functional aspects both in humans and in preclinical models under physiological and pathological conditions.
The knowledge provided during the course will enable the student to develop a critical ability regarding the use of techniques for the analysis of neuronal activity and its modulation, discussing scientific works with the professor and producing an individual manuscript.

At the end of the course the student will have acquired:
a) in-depth knowledge of the neurophysiological basis underlying the functioning of brain circuits and the possibility of modulating their activity;
b) detailed understanding of neuromodulation approaches, focusing particularly on noninvasive techniques;
c) ability to apply the acquired knowledge for neurophysiological analyses, particularly in preclinical models of neurological and neuropsychiatric disorders;
d) ability to analyze and understand recent trends and developments in the field.

Prerequisites and basic notions

Basics of biology, biophysics, biochemistry and genetics; fundamental principles of cellular and membrane physiology

Program

Neuronal networks and complexity (sensation and perception); communication between neurons; glial cells and interactions with neurons; extracellular recording techniques; brain circuits, learning and behavior; physiological basis of neuromodulation; neuromodulation techniques

Bibliography

Didactic methods

Lectures with slide presentation; discussion of articles and scientific reviews

Learning assessment procedures

Oral exam and presentation of a paper (from a scientific article)

Evaluation criteria

Knowledge of the topics and in-depth analysis of the contents

Criteria for the composition of the final grade

final mark out of thirty

Exam language

Inglese