Teaching code

4S000089

Teacher

Credits

2

Language

Italian

Scientific Disciplinary Sector (SSD)

BIO/10 - BIOCHEMISTRY

Period

TPALL 1° ANNO 1° SEMESTRE dal Oct 1, 2018 al Dec 21, 2018.

Lessons timetable Moodle Seminars

To show the organization of the course that includes this module, follow this link:  Course organization

Learning outcomes

To transmit the main chemical principles to allow comprehension of the mechanisms that control matter interaction. To explain macromolecules organization and the principle of metabolism. To understand factors that regulate the main metabolic pathways. Emphasis will be on physiological and pathological processes associated to the main biochemical functions in order to control and develope new strategies to protect the environment and and work location.

Program

Basic concepts in Chemistry and organic chemistry:
the matter: atoms, molecules.
Atomic organization: atomic orbitals, energy levels
Chemical bound: covalent, ionic. Week interactions: hydrogen bond, van der Waals, hydrophobic interaction.
Water.
Molecules: properties and interactions in water.
Solutions: definitions and concentrations (Molarity), osmosis.
Buffer, pH.
Chemical reactions: red/ox.
Thermodynamic: Free energy (G), energetic potential of ATP, coupled reactions.

Biochemistry
Proteins: amino acids, peptide bound. Protein structures.
Post translational modifications. Quality control for secreted proteins.
Enzymes: kinetic, mechanism of action. Enzymatic inhibition. Allosteric regulation.
Nucleic acids: nucleotides, DNA, RNA
Sugars: simple and complex sugars. sugar bond, polysaccharides (starch and glycogen).
Glycoproteins: blood groups.
Membranes: properties, phospholipids, double layer.
Lipids: fatty acids, cholesterol.
Metabolism.
general principles, regulations, hormones, vitamins.
Sugar metabolism: glycolysis, regulations, alcohol fermentation, lactic fermentation. Pentose cycle.
Citric acid cycle: oxidative phosphorylation, ATP synthase
Gluconeogenesis.
Fatty acid metabolism: fatty acid digestion, beta oxidation, ketone bodies.
Fatty acid synthesis
Protein metabolism: transamination. Urea cycle.
Protein biosynthesis.

Examination Methods

Assessment for learning will be through a written multiple choice. 20 questions in each test. Test is formulated by an automated system by the "Centro docimologico di Ateneo". Basically, questions are randomly chosen from a database made by the teacher. Questions are randomly mixed in each test. A question and an answer sheet are nominated for each student. Answer sheet are automatically read by the system and results are sent to the teacher.