Studying at the University of Verona
Here you can find information on the organisational aspects of the Programme, lecture timetables, learning activities and useful contact details for your time at the University, from enrolment to graduation.
Study Plan
This information is intended exclusively for students already enrolled in this course.If you are a new student interested in enrolling, you can find information about the course of study on the course page:
Laurea magistrale in Molecular and Medical Biotechnology - Enrollment from 2025/2026The Study Plan includes all modules, teaching and learning activities that each student will need to undertake during their time at the University.
Please select your Study Plan based on your enrollment year.
1° Year
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1 course among the following1 course among the following2 courses among the following3 courses among the following2° Year activated in the A.Y. 2024/2025
| Modules | Credits | TAF | SSD |
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| Modules | Credits | TAF | SSD |
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1 course among the following1 course among the following2 courses among the following3 courses among the following| Modules | Credits | TAF | SSD |
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| Modules | Credits | TAF | SSD |
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2 courses among the following ("CLINICAL PROTEOMICS" 1ST and2ND YEAR; the other courses 2nd year only)Legend | Type of training activity (TTA)
TAF (Type of Educational Activity) All courses and activities are classified into different types of educational activities, indicated by a letter.
Farming molecolare (2024/2025)
Teaching code
4S003677
Teacher
Coordinator
Credits
6
Language
English
Scientific Disciplinary Sector (SSD)
BIO/15 - PHARMACEUTICAL BIOLOGY
Period
Semester 1 dal Oct 1, 2024 al Jan 31, 2025.
Courses Single
Authorized
Learning objectives
The course aims to give the students notions of the use of recombinant systems for the production of biopharmaceuticals. In particular, the course will be focused on the biomolecular techniques used for the expression of recombinant proteins in prokaryotic and eukaryotic systems and the downstream processing and purification for their large-scale production. The different platforms used for the recombinant expression will be studied and compared. The different US and EU normative procedures for biopharmaceutical commercialization will be evaluated and compared. Specific examples of biopharmaceutical produced in recombinant systems and their therapeutic applications like for vaccines and antibodies will be discussed and studied.
Prerequisites and basic notions
Basic knowledge of molecular biology, biochemistry and immunology
Program
General introduction to the concept of Molecular farming
Definition of biopharmaceuticals and drugs
Route for biopharmaceuticals approval.
The Clinical Trials and the main Regulatory Agencies.
GMP definition
Intellectual Property for Biopharmaceuticals
Biosimilars and Bioequivalence
Platforms for the heterologous production of recombinant proteins with a focus on the relative upstream processes (bacteria, yeasts, plants, baculovirus/insect cells, mammalian cells and transgenic animals)
Downstream processing: continuous and discontinuous production
The main categories of biopharmaceuticals: Antibodies, Vaccines, Toxins and Hormones
Heterologous expression of antibodies
The clinical use of antibodies from pathogen defence to chronic diseases
Active immunization: the vaccines
Production of vaccines
Immunogenicity
Post-translational modifications and glycoengineering of platforms
Immunological tolerance
T-cells Biotechnology: CAR-T cells
Production of peptides and their clinical and daignostic applications
Techno-economic analysis for the production of recombinant proteins
Patent, Clinical Trials and Description of a Biopharmaceutical. TEA analysis development
Didactic methods
In-person lessons with co-teaching relating to the techno-economic analysis part with a teacher of international origin with a high scientific profile
Learning assessment procedures
Oral exam with the availability of a non-appeal date for each student. Development of group work (groups of 3 people) relating to a technical-economic analysis for a defined disease and related treatments based on biopharmaceuticals with related patent panorama. Individual paper relating to the production of a specific bio-drug with analysis of a selection of Clinical Trials (optional)
Evaluation criteria
Knowledge of the topics covered during the course. Ability to research individually and in groups on recent scientific literature and on specialist sites for biopharmaceuticals
Criteria for the composition of the final grade
Oral exam: maximum score 26/30
Group work: 2/30
Individual work: 2/30
Exam language
Inglese /italiano
