The teaching is organized as follows:

Learning outcomes

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MM: BIOCHIMICA
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Basic knowledge of general and organic chemistry preparatory for biochemistry. Structure-function relationship of the most important biological macromolecules and of the metabolic regulation at the molecular level. Cross-talk between the different biochemical pathways and the energy level changes associated.
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MM: FISICA APPLICATA
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The course aims to provide: • the foundations of the experimental method, which is the basis of modern science and technology disciplines • basic knowledge (physical quantities and physical laws) of mechanical phenomena, with examples and bioscience applications(biomechanics). At the end of the course students will apply their knowledge to solve physics problems.
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MM: STATISTICA MEDICA
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The course is aimed at enabling the student to: - estimate accuracy and precision of measurements performed in the biomedical field; - properly synthetize and summarize the information collected on a series of patients; - compute the probability of a single event or several events - generalize findings from samples to the original population
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MM: BIOLOGIA APPLICATA
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The course aims to give basic knowledge about living organism characteristic: procariots, eucariots, viruses, through the acquisition of the fundamental concepts of biology and of the structural, functional and molecular principles of cellular processes. Moreover, it aims to provide the basic knowledge on the fundamental concepts of genetics and transmission of hereditary characters.

Program

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MM: BIOCHIMICA
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PREPARATORY CHEMISTRY (several notions are included in the basic knowledge required)
1. Atomic structure and periodic properties of the elements: matter composition, atom, atomic particles; atomic theory; quantum numbers, and orbitals; electronic configuration, periodic table and chemical reactivity of the elements; electronic affinity, electronegativity.
2. The chemical bond: molecules and ions; ionic and covalent bond; intermolecular forces; hydrogen bond.
3. Solutions and acid-base reactions: concentration of the solutions, acid-base theories of Arrhenius and Brőnsted-Lowry; hydracids, hydroxides, oxyacids; acid-base reactions; pH and buffer solutions.
4. Organic chemistry notions: carbon atom properties; hybrid orbitals; organic compounds classification: functional groups; hydrocarbons; alcohols, ethers, thiols, amines, aldehydes and ketones; carboxylic acids, esters, anhydrides.

BIOCHEMISTRY
1. Constitutive elements of the living matter: polymeric structure of the biological macromolecules.
2. Protein structure and function: aminoacid classification, buffering power, peptide bond, levels of protein structure; fibrous and globular proteins; hemoglobin and myoglobin: structure, function, factors influencing the oxygen bond; hemoglobin variants; enzymes: classification, role in the chemical reactions, regulation of the enzymatic activity.
3. Vitamins: hydro- and lypo-soluble vitamins; co-enzymes.
4. Bio-energetics: metabolism; chemical transformations in the cell; spontaneous and non-spontaneous reactions of the metabolic reactions; ATP as “energy exchange coin”; biologically relevant redox reactions.
5. Carbohydrates structure and metabolism: mono- and disaccharides; polysaccharides; glycoconjugates; glycolysis and its regulation; gluconeogenesis; hints of the penthose phosphate pathway; synthesis of the glycogen.
6. Citric acid cycle and oxidative phosphorylation: mitochondria; acetyl-CoA synthesis; citric acid cycle control; respiratory chain and electron transport; ATP synthesis.
7. Lipids structure and metabolism: structural lipids and biological membranes; cholesterol; stock-reserve lipids; lipids digestion and fatty acid β-oxydation; keton bodies formation; hints of fatty acids biosynthesis.
8. Aminoacid metabolism: hints of gluco- and keto-forming aminoacids; transamination and oxidative deamination; the urea cycle.

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MM: FISICA APPLICATA
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Physical quantities and their measurement.
Definition of a physical quantity. Unit consistency and conversions. Standards and units. Uncertainty and significant figures.
The foundation of classical mechanics.
Forces and motion. Newton’s laws of motion and their application. Motion description: displacement, velocity and acceleration. Work and kinetic energy. Potential energy and energy conservation. Momentum. Torque and angular momentum.
Biomechanics.
Lever systems in the human body. Equilibrium in the human body. Elements of mechanics of movement.

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MM: STATISTICA MEDICA
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Use of statistics in health data

Collection and presentation
Measurement procedure and Variable types
Precision and accuracy of a measurement procedure
Tables 1 and 2 entries
Absolute and relative frequencies
Cumulative frequencies
Graphical representation of the data

Position and dispersion measures
Mode
Quantiles and median
Simple and weighted mean
Range and standard deviation
Coefficient of variation

Introduction to probability
Definition of probability
Rule of addition and multiplication
Independent and conditional probability

Introduction to statistical inference
The concept of statistical inference
Inference techniques:
Binomial and Gauss distribution, confidence intervals and Hypothesis testing

Diagnostic and screening test:Sensitivity, specificity, positive predictive value of screening

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MM: BIOLOGIA APPLICATA
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•Characteristics of the living beings
•Chemistry of living organisms and biological molecules
•Prokaryotic and eukaryotic cell: organization of the cell; internal membranes and compartmentalization; organelles, characteristics and functions: nucleus, ribosomes, RER, REL, Golgi, lysosomes, peroxisomes, cytoskeleton, cell wall, extracellular matrix. Animal and plant cells. Mitochondria and plastids (chloroplasts, amyloplasts, chromoplasts) and endosymbiont theory.
•Biological membranes: structure and proposed models; passage of materials across cell membranes: passive transport (facilitated diffusion and simple), osmosis, directly and indirectly active transport, co-transport. Exocytosis and endocytosis. Anchoring, tight and gap cell junctions in animal and plant cells.
•Cell communication: types of cellular communication: endocrine, paracrine, autocrine and iuxtacrine. Sending and receiving the signal.
•Organization of DNA in chromosomes, mitosis and meiosis. DNA and proteins, nucleosomes, heterochromatin, euchromatin, chromosome condensation. The cell cycle and its regulation. Mitosis, meiosis and sexual reproduction
•DNA and its role in heredity. DNA structure and replication.
•Gene expression: transcription, genetic code and translation. Gene definition.
•DNA mutations and mutagenesis
•Hereditary character transmission and Mendel’s laws; definition of phenotype, genotype, locus, gene, dominant and recessive allele, homozygosity and heterozygosity. Segregation and independent assortment. Independence and association. Crossing-over and recombination. Genetic determination of sex. Gene interactions. Incomplete dominance, condominance, multiple alleles, epistasis and polygeny.
•The human genome: karyotype analysis and pedigrees; autosomal recessive, autosomal dominant, X-linked diseases.

Bibliography

Examination Methods

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MM: BIOCHIMICA
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Written test: 10 multiple choice questions (2 points each), plus 2 open questions (0 to 5 points each)
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MM: FISICA APPLICATA
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Written exam consisting in simple problem solving. After passing the written test an oral examination will assess the understanding of the main concepts and examine the conduct of the written test.
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MM: STATISTICA MEDICA
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The exam consists of a written test consisting of multiple-choice tests and exercises.
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MM: BIOLOGIA APPLICATA
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Written test (multiple choice questions and open-ended questions)